Short-term increases in sugar consumption could increase the risk of inflammatory bowel disease and have a significant impact on our health, a new study suggests. Researchers found that mice had an increased susceptibility to chemically induced colitis and more severe symptoms after only two days of a high-sugar diet compared with those eating a balanced diet.
Scientists have shed new light on one of the central mysteries of solar physics: how energy from the Sun is transferred to the star's upper atmosphere, heating it to 1 million degrees Fahrenheit and higher in some regions, temperatures that are vastly hotter than the Sun's surface.
Everyone knows that gaining excess weight during one pregnancy is bad, but clinicians rarely consider weight gains and losses from one pregnancy to the next -- especially in normal-weight women. But researchers have now found that among normal-weight women, fluctuating weight gain and loss in the first pregnancy is often repeated in subsequent pregnancies -- and is associated with higher risk of several pregnancy-related complications.
Deletion of the gene that codes for an enzyme called GSTM1 increased kidney injury in mice with hypertension and kidney disease, but supplementing the diet with broccoli powder lessened kidney injury in the genetically altered mice. In humans, high consumption of broccoli and other cruciferous vegetables was linked with a lower risk of kidney failure, primarily in individuals lacking GSTM1.
When will the next eruption take place? Examination of samples from Indonesia's Mount Merapi show that the explosivity of stratovolcanoes rises when mineral-rich gases seal the pores and microcracks in the uppermost layers of stone. These findings result in new possibilities for the prediction of an eruption.
Two pathways diverged in a chemical synthesis, and one molecule took them both. Chemists have studied how molecular building blocks can either form a spherical cage or an ultrathin sheet that shows some of the basic properties of a ''smart'' material that can respond to its environment.
The western corn rootworm, one of the world's most damaging maize pests, can use plant defense compounds to defend itself against its own natural enemies, so-called entomopathogenic nematodes. However, the nematodes can become immune against these compounds in turn, which enhances their ability to fight the western corn rootworm, as researchers show. This mechanism may contribute to improving biological pest control.
Up to one in five patients treated for idiopathic normal pressure hydrocephalus, iNPH, also develop Alzheimer's disease, according to a new study. The researchers were able to predict the development of Alzheimer's disease by using the Disease State Index, DSI, that combines patient-specific data from various sources.
Following a nearly 25-year search across three continents, parents of a pair of sisters -- who as children slowly became paralyzed from the waist down -- finally have a diagnosis. Thanks to a chance viewing on French TV of a story about another physically disabled child who regained her mobility after being diagnosed at TGen, the parents of the two sisters contacted TGen, hoping to end their decades-long diagnostic odyssey.
Lichens -- a combo of fungus and algae -- can grow on bare rocks, so scientists thought that lichens were some of the first organisms to make their way onto land from the water, changing the planet's atmosphere and paving the way for modern plants. But a closer look at the DNA of the algae and fungi that form lichens shows that lichens likely evolved millions of years after plants.
A new genetic study demonstrates that, at the end of the Iron Age, Finland was inhabited by separate and differing populations, all of them influencing the gene pool of modern Finns. The study is so far the most extensive investigation of the ancient DNA of people inhabiting the region of Finland.
A new study into the interplay between mobility and the 2013 and 2014 dengue outbreaks in Singapore has uncovered a legal void around access to mobile phone data -- information that can prove vital in preventing the spread of infectious diseases.
Nucleotide-binding, leucine-rich repeat receptors (NLRs) perceive pathogen effectors to trigger plant immunity. Biochemical mechanisms underlying plant NLR activation have until now remained poorly understood. We reconstituted an active complex containing the Arabidopsis coiled-coil NLR ZAR1, the pseudokinase RKS1, uridylated protein kinase PBL2, and 2'-deoxyadenosine 5'-triphosphate (dATP), demonstrating the oligomerization of the complex during immune activation. The cryo-electron microscopy structure reveals a wheel-like pentameric ZAR1 resistosome. Besides the nucleotide-binding domain, the coiled-coil domain of ZAR1 also contributes to resistosome pentamerization by forming an α-helical barrel that interacts with the leucine-rich repeat and winged-helix domains. Structural remodeling and fold switching during activation release the very N-terminal amphipathic α helix of ZAR1 to form a funnel-shaped structure that is required for the plasma membrane association, cell death triggering, and disease resistance, offering clues to the biochemical function of a plant resistosome.