CRISPR/Cas enables the targeted deactivation of genes by cutting DNA at pre-determined sites. This is accomplished by providing the Cas enzyme with a genetic zip code. Using an entire library of zip codes, it is then possible to simultaneously probe multiple sites within the genome, for example to determine which genes are essential for cancer cell survival. This could revolutionize drug discovery.
Researchers have shown that selectively destroying cancerous prostate tissue is as effective as complete prostate removal or radiation therapy while preserving more sexual and urinary function than the other treatments.
An adhesive gel packed with light-activated chemicals can seal cuts or ulcers on the cornea -- the clear surface of the eye -- and then encourage the regeneration of corneal tissue, according to a preclinical study. The new technology, named GelCORE (gel for corneal regeneration), could one day reduce the need for surgery to repair injuries to the cornea, including those that would today require corneal transplantation.
Here's something to chew on: One in four people are impacted by defects of the temporomandibular - or jaw - joint. Despite the pervasiveness of this affliction, treatments are lacking, and many sufferers resort to palliative measures to cope with the pain and debilitation it causes.
Exposure to common agricultural pesticides before birth and in the first year of life is associated with a small to moderately increased risk of autism spectrum disorder (ASD) compared with infants of women without such exposure, finds a new study.
Researchers call for greater regulation and transparency as analysis of medicines-related apps found most directly shared user data -- including sensitive health data -- with third parties, posing an unprecedented privacy risk.
A new study found that people who use ride-hailing are willing to pay more to avoid driving, including the stress and cost of parking. As a result, cities are seeing a reduction in parking demand, particularly at restaurants and bars, event venues, and airports. That reduction could push cities to reconsider and replace parking infrastructure, leading to more vibrant cities and less dependency on cars.
Several previous studies have demonstrated that moderate alcohol consumption is linked with less severe disease and better quality of life in patients with rheumatoid arthritis, but a new study suggests that this might not be because drinking alcohol is beneficial.
Combining medications that suppress the immune system has been successful in treating young patients with Crohn's disease, but some physicians have been reluctant to use this strategy in older patients because of concerns about safety. Now a new study indicates that older patients can be safely and effectively treated with such combined immunosuppression as well.
A multi-disciplinary team of biological engineers, microbiologists, and systems biologists, whose goal it is to uncover the causes of tolerance to infection exhibited by certain individuals or species, has now succeeded in modeling infection of human colon with EHEC in vitro using a microfluidic Organ-on-a-Chip (Organ Chip) culture device.
Whole-body regeneration is accompanied by complex transcriptomic changes, yet the chromatin regulatory landscapes that mediate this dynamic response remain unexplored. To decipher the regulatory logic that orchestrates regeneration, we sequenced the genome of the acoel worm Hofstenia miamia, a highly regenerative member of the sister lineage of other bilaterians. Epigenomic profiling revealed thousands of regeneration-responsive chromatin regions and identified dynamically bound transcription factor motifs, with the early growth response (EGR) binding site as the most variably accessible during Hofstenia regeneration. Combining egr inhibition with chromatin profiling suggests that Egr functions as a pioneer factor to directly regulate early wound-induced genes. The genetic connections inferred by this approach allowed the construction of a gene regulatory network for whole-body regeneration, enabling genomics-based comparisons of regeneration across species.